منابع مشابه
Nonmyeloablative, HLA-haploidentical bone marrow transplantation with high dose, post-transplantation cyclophosphamide
Allogeneic stem cell transplantation (SCT) from an HLA-haploidentical relative provides a potentially curative treatment option for hematologic malignancies patients who lack a suitably HLA-matched donor. The greatest challenge to performing HLA-haploidentical SCT has been high rates of graft failure and severe graft-versus-host disease (GVHD). Our group has been exploring high dose, post-trans...
متن کاملAn overview of conditioning regimens for haploidentical stem cell transplantation with post-transplantation cyclophosphamide.
Haploidentical related donors are an attractive alternative source of stem cells for allogeneic stem cell transplantation due to widespread availability and ease of stem cell procurement. Historically, haploidentical stem cell transplantation (HaploSCT) with extensive T-cell depletion has been associated with high rates of infectious complications and nonrelapse mortality (NRM). Post-transplant...
متن کاملComparable composite endpoints after HLA-matched and HLA-haploidentical transplantation with post-transplantation cyclophosphamide.
Composite endpoints that not only encompass mortality and relapse, but other critical post-transplant events such as graft-versus-host disease, are being increasingly utilized to quantify survival without significant morbidity after allogeneic blood or marrow transplantation. High-dose, post-transplantation cyclophosphamide reduces severe graft-versus-host disease with allogeneic marrow transpl...
متن کاملRenal transplantation under cyclophosphamide.
BEGINNING 15 mo ago, at the University of Colorado, the alkylating agent, cyclophosphamide (Cytoxan), has been given an extensive clinical trial in the treatment of whole organ recipients both early and late after transplantation. This communication will deal only with those cases of renal homotransplantation in which cyclophosphamide was used from the outset. The late substitution of cyclophos...
متن کاملCyclophosphamide and human organ transplantation.
S Cyclophosphamide, a drug that has not ummCH"Y • 1 had· 1 . preVIOUS y an unportant ro e ill whole-organ transplantation, was given as a primary immunosuppressant to one liver and eleven kidney recipients, in combination with prednisone and horse antilymphocyte globulin. One of the patients died despite good renal-graft function. Two kidneys from a common cadaveric donor failed. The other nine...
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ژورنال
عنوان ژورنال: JACC: CardioOncology
سال: 2021
ISSN: 2666-0873
DOI: 10.1016/j.jaccao.2021.04.004